Historical data suggest that over 100 pairs of the Peregrine Falcon (Falco peregrinus) were nesting in California prior to the mid-1940s. Because of the deleterious effects of DDE, a sharp decline began in the 1950s, and by 1970 only about 5% of the population remained. Following pesticide restrictions and aggressive management and recovery efforts using captive-bred Peregrines, the population rebounded rapidly and continues to increase into the 21st century. Although information necessary to enable the species’ conservation was circulated, few details on its historical and recent breeding status at either the statewide or regional level have been published. Here we report available details for breeding Peregrines in the eastern Sierra Nevada of Mono and Inyo counties. Data on seven suspected historical breeding locations are sparse. Since 2005, breeding has been verified or suspected at 14 locations, 11 spanning the length of Mono County and 3 at dispersed locations in Inyo County. Of these, four were newly identified in 2025. Despite the dramatic comeback, vigilance and monitoring are needed. Notably, Peregrine mortality from highly pathogenic avian influenza may be an important cause of population decline in many regions of North America, including California, since 2022. Although the effects appear to have been greatest in coastal areas, where the falcons depend heavily on shorebirds and waterfowl (known to carry avian flu), problems have surfaced inland, including possibly at the base of the eastern Sierra where these prey concentrate in spring and summer at saline lakes and freshwater reservoirs.