The Peregrine Falcon (Falco peregrinus) is found almost worldwide, but few have been documented nesting in southwestern Arizona or southeastern California. Here we report on Peregrine Falcon nests discovered at two locations, both suspected in 2012 and confirmed in 2013. One is the first documented Peregrine Falcon nest on the lower Colorado River south of Parker, Arizona, and a first record for Imperial County, California (Guy McCaskie, California Bird Records Committee, pers. comm.), and the other is the first recorded for Yuma County, Arizona, at Kofa National Wildlife Refuge (NWR). The eyrie along the Colorado River was more easily accessible than the Kofa eyrie, so we observed it at a much closer range, enabling recording of more detailed information, and we were able to visit it more frequently, two to six times per month from March through September.